Hypothalamic inflammation and the development of an obese phenotype induced by high-fat diet consumption is exacerbated in alpha7 nicotinic cholinergic receptor knockout mice.

doi:10.1016/j.foodres.2023.113808

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Article

Hypothalamic inflammation and the development of an obese phenotype induced by high-fat diet consumption is exacerbated in alpha7 nicotinic cholinergic receptor knockout mice.

Food research international (Ottawa, Ont.) - 1 Jan 2024

Lopes Priscilla Karla Fernandes, Costa Suleyma de Oliveira, Simino Laís A de Paula, Chaves Wenicios Ferreira, Silva Franciely Alves, Costa Caroline Lobo, Milanski Marciane, Ignacio-Souza Leticia Martins, Torsoni Adriana Souza, Torsoni Marcio Alberto

Abstract excerpt

Hypothalamic inflammation and metabolic changes resulting from the consumption of high-fat diets have been linked to low grade inflammation and obesity. Inflammation impairs the hypothalamic expression of α7 nicotinic acetylcholine receptor (α7nAChR). The α7nAChR is described as the main component of the anti-inflammatory cholinergic pathway in different inflammation models. To assess whether the reduction in...

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PMID: 38163714
DOI: 10.1016/j.foodres.2023.113808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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