Article
C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet.
Diabetologia - 1 Jun 2007
Poggi M, Bastelica D, Gual P, Iglesias M A, Gremeaux T, Knauf C, Peiretti F, Verdier M, Juhan-Vague I, Tanti J F, Burcelin R, Alessi M C
Abstract excerpt
AIMS/HYPOTHESIS: Inflammation is associated with obesity and has been implicated in the development of diabetes and atherosclerosis. During gram-negative bacterial infection, lipopolysaccharide causes an inflammatory reaction via toll-like receptor 4 (TLR4), which has an essential function in the induction of innate and adaptative immunity. Our aim was to determine what role TLR4 plays in the development of...
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