Article

Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Obesity and metabolic disorders, such as metabolic syndrome (MetS) facilitate the development of neurodegenerative diseases and cognitive decline. Persistent neuroinflammation plays an important role in this process. Pleiotrophin (PTN) is a cytokine that regulates energy metabolism and high-fat diet (HFD)-induced neuroinflammation, suggesting that PTN could play an important role in the connecti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e9a7425-2f90-5a46-b4b6-c55ef705cb69
DOI: 10.1101/2024.09.23.614574

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampusDOI 10.1101/2024.09.23.614574Read

Metabolic syndrome in New Zealand Obese mice promotes microglial-vascular interactions and reduces microglial plasticitySemantic proximity Read

Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesitySemantic proximity Read

Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cellsSemantic proximity Read

Fat food exacerbates post-prandial hypothalamic inflammation involving GFAP+ cells and microgliaSemantic proximity Read

PBMC transcriptome reveals an early metabolic risk profile in young rats with metabolically obese, normal-weight phenotype.Semantic proximity Read

The Metabolically Obese, Normal-Weight Phenotype in Young Rats Is Associated with Cognitive Impairment and Partially Preventable with Leptin Intake during Lactation.Semantic proximity Read

Altered cognitive function in obese patients: relationship to gut floraSemantic proximity Read

Neuroinflammatory basis of metabolic syndromeSemantic proximity Read

PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and NeuroinflammationSemantic proximity Read

Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible <i>versus</i> resistant male mice upon repeated social defeatSemantic proximity Read

Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunctionSemantic proximity Read

Complement 3a Receptor mediates high fat diet induced hypothalamic accumulation of lipid associated microglia to regulate neuroinflammation and obesitySemantic proximity Read