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Article

Increased hypothalamic inflammation associated with the susceptibility to obesity in rats exposed to high-fat diet.

Experimental diabetes research - 1 Jan 2012

Wang Xiaoke, Ge Aiguo, Cheng Mengjie, Guo Fangfang, Zhao Min, Zhou Xiaoqi, Liu Liegang, Yang Nianhong

Abstract excerpt

Inflammation has been implicated in the hypothalamic leptin and insulin resistance resulting defective food intake during high fat diet period. To investigate hypothalamic inflammation in dietary induced obesity (DIO) and obesity resistant (DIO-R) rats, we established rat models of DIO and DIO-R by feeding high fat diet for 10 weeks. Then we switched half of DIO and DIO-R rats to chow food and the other half to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22844271
DOI: 10.1155/2012/847246
PMCID: PMC3401545

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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