Article
GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Oct 2013
Ito Yoshihiro, Banno Ryoichi, Shibata Miyuki, Adachi Koichi, Hagimoto Shigeru, Hagiwara Daisuke, Ozawa Yoshiharu, Goto Motomitsu, Suga Hidetaka, Sugimura Yoshihisa, Bettler Bernhard, Oiso Yutaka, Arima Hiroshi
Abstract excerpt
There is evidence suggesting that the GABA system in the arcuate nucleus, where orexigenic neuropeptide Y and agouti-related peptide as well as anorexigenic proopiomelanocortin (POMC) are expressed, plays an important role in energy balance. In this study, we generated POMC-specific GABAB receptor-deficient [knock-out (KO)] mice. Male KO mice on a high-fat diet (HFD) showed mild increases in body weight (BW) at...
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