Article
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Jan 2009
Milanski Marciane, Degasperi Giovanna, Coope Andressa, Morari Joseane, Denis Raphael, Cintra Dennys E, Tsukumo Daniela M L, Anhe Gabriel, Amaral Maria E, Takahashi Hilton K, Curi Rui, Oliveira Helena C, Carvalheira José B C, Bordin Silvana, Saad Mário J, Velloso Lício A
Abstract excerpt
In animal models of diet-induced obesity, the activation of an inflammatory response in the hypothalamus produces molecular and functional resistance to the anorexigenic hormones insulin and leptin. The primary events triggered by dietary fats that ultimately lead to hypothalamic cytokine expression and inflammatory signaling are unknown. Here, we test the hypothesis that dietary fats act through the activation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.