Article
LA-GEM: imputation of gene expression with incorporation of Local Ancestry.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2024
Mishra Mrinal, Nahlawi Layan, Zhong Yizhen, De Tanima, Yang Guang, Alarcon Cristina, Perera Minoli A
Abstract excerpt
Gene imputation and TWAS have become a staple in the genomics medicine discovery space; helping to identify genes whose regulation effects may contribute to disease susceptibility. However, the cohorts on which these methods are built are overwhelmingly of European Ancestry. This means that the unique regulatory variation that exist in non-European populations, specifically African Ancestry populations, may not...
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