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Article

METRO: Multi-ancestry transcriptome-wide association studies for powerful gene-trait association detection.

American journal of human genetics - 5 May 2022

Li Zheng, Zhao Wei, Shang Lulu, Mosley Thomas H, Kardia Sharon L R, Smith Jennifer A, Zhou Xiang

Abstract excerpt

Integrative analysis of genome-wide association studies (GWASs) and gene expression studies in the form of a transcriptome-wide association study (TWAS) has the potential to better elucidate the molecular mechanisms underlying disease etiology. Here we present a method, METRO, that can leverage gene expression data collected from multiple genetic ancestries to enhance TWASs. METRO incorporates expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35334221
DOI: 10.1016/j.ajhg.2022.03.003
PMCID: PMC9118130

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