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Article

CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data.

American journal of human genetics - 3 Jul 2025

Head S Taylor, Dai Qile, Schildkraut Joellen, Cutler David J, Yang Jingjing, Epstein Michael P

Abstract excerpt

A transcriptome-wide association study (TWAS) is a popular statistical method for identifying genes whose genetically regulated expression (GReX) component is associated with a trait of interest. Most TWAS approaches fundamentally assume that the training dataset (used to fit the gene expression prediction model) and target genome-wide association study (GWAS) dataset are from the same ancestrally homogeneous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40516523
DOI: 10.1016/j.ajhg.2025.05.010
PMCID: PMC12256880

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