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Article

Deciphering the causal relationship between blood pressure and regional white matter integrity: A two-sample Mendelian randomization study.

Journal of neuroscience research - 1 Sept 2023

Ye Zhenyao, Mo Chen, Liu Song, Gao Si, Feng Li, Zhao Boao, Canida Travis, Wu Yu-Chia, Hatch Kathryn S, Ma Yizhou, Mitchell Braxton D, Hong L Elliot, Kochunov Peter, Chen Chixiang, Zhao Bingxin, Chen Shuo, Ma Tianzhou

Abstract excerpt

Elevated arterial blood pressure (BP) is a common risk factor for cerebrovascular and cardiovascular diseases, but no causal relationship has been established between BP and cerebral white matter (WM) integrity. In this study, we performed a two-sample Mendelian randomization (MR) analysis with individual-level data by defining two nonoverlapping sets of European ancestry individuals (genetics-exposure set:...

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Identifiers

PMID: 37330925
DOI: 10.1002/jnr.25205
PMCID: PMC10444533

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