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Article

A new Mendelian Randomization method to estimate causal effects of multivariable brain imaging exposures.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2022

Mo Chen, Ye Zhenyao, Ke Hongjie, Lu Tong, Canida Travis, Liu Song, Wu Qiong, Zhao Zhiwei, Ma Yizhou, Hong L Elliot, Kochunov Peter, Ma Tianzhou, Chen Shuo

Abstract excerpt

The advent of simultaneously collected imaging-genetics data in large study cohorts provides an unprecedented opportunity to assess the causal effect of brain imaging traits on externally measured experimental results (e.g., cognitive tests) by treating genetic variants as instrumental variables. However, classic Mendelian Randomization methods are limited when handling high-throughput imaging traits as exposures...

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PMID: 34890138
PMCID: PMC8669774

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