Article
Efficient estimation for large-scale linkage disequilibrium patterns of the human genome.
eLife - 27 Dec 2023
Huang Xin, Zhu Tian-Neng, Liu Ying-Chao, Qi Guo-An, Zhang Jian-Nan, Chen Guo-Bo
Abstract excerpt
In this study, we proposed an efficient algorithm (X-LD) for estimating linkage disequilibrium (LD) patterns for a genomic grid, which can be of inter-chromosomal scale or of small segments. Compared with conventional methods, the proposed method was significantly faster, dropped from O(nm2) to O(n2m)-n the sample size and m the number of SNPs, and consequently we were permitted to explore in depth unknown or...
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