Article
A fine-scale linkage-disequilibrium measure based on length of haplotype sharing.
American journal of human genetics - 1 Apr 2006
Wang Yan, Zhao Lue Ping, Dudoit Sandrine
Abstract excerpt
High-throughput genotyping technologies for SNPs have enabled the recent completion of the International HapMap Project (phase I), which has stimulated much interest in studying genomewide linkage-disequilibrium (LD) patterns. Conventional LD measures, such as D' and r(2), are two-point measurements, and their relationship with physical distance is highly noisy. We propose a new LD measure, Delta , defined in...
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