Article
High-resolution haplotype structure in the human genome.
Nature genetics - 1 Oct 2001
Daly M J, Rioux J D, Schaffner S F, Hudson T J, Lander E S
Abstract excerpt
Linkage disequilibrium (LD) analysis is traditionally based on individual genetic markers and often yields an erratic, non-monotonic picture, because the power to detect allelic associations depends on specific properties of each marker, such as frequency and population history. Ideally, LD analysis should be based directly on the underlying haplotype structure of the human genome, but this structure has remained...
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