Article
The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern.
Genome research - 1 Apr 2005
De La Vega Francisco M, Isaac Hadar, Collins Andrew, Scafe Charles R, Halldórsson Bjarni V, Su Xiaoping, Lippert Ross A, Wang Yu, Laig-Webster Marion, Koehler Ryan T, Ziegle Janet S, Wogan Lewis T, Stevens Junko F, Leinen Kyle M, Olson Sheri J, Guegler Karl J, You Xiaoqing, Xu Lily H, Hemken Heinz G, Kalush Francis, Itakura Mitsuo, Zheng Yi, de Thé Guy, O'Brien Stephen J, Clark Andrew G, Istrail Sorin, Hunkapiller Michael W, Spier Eugene G, Gilbert Dennis A
Abstract excerpt
The extent and patterns of linkage disequilibrium (LD) determine the feasibility of association studies to map genes that underlie complex traits. Here we present a comparison of the patterns of LD across four major human populations (African-American, Caucasian, Chinese, and Japanese) with a high-resolution single-nucleotide polymorphism (SNP) map covering almost the entire length of chromosomes 6, 21, and 22....
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