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Article

HOXA10 promotes Gdf5 expression in articular chondrocytes

20 Dec 2023

Abstract excerpt

Growth differentiation factor 5 (GDF5), a BMP family member, is highly expressed in the surface layer of articular cartilage. The GDF5 gene is a key risk locus for osteoarthritis and Gdf5-deficient mice show abnormal joint development, indicating that GDF5 is essential in joint development and homeostasis. In this study, we aimed to identify transcription factors involved in Gdf5 expression by performing two-step...

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PMID: 38123662
DOI: 10.1038/s41598-023-50318-7

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