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Article

Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis.

Annals of the rheumatic diseases - 1 Mar 2018

Pregizer Steven K, Kiapour Ata M, Young Mariel, Chen Hao, Schoor Michael, Liu Zun, Cao Jiaxue, Rosen Vicki, Capellini Terence D

Abstract excerpt

OBJECTIVES: Given the role of growth and differentiation factor 5 (GDF5) in knee development and osteoarthritis risk, we sought to characterise knee defects resulting from Gdf5 loss of function and how its regulatory regions control knee formation and morphology. METHODS: The brachypodism (bp) mouse line, which harbours an inactivating mutation in Gdf5, was used to survey how Gdf5 loss of function impacts knee...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Regulatory Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 29311146
DOI: 10.1136/annrheumdis-2017-212475
PMCID: PMC6338229

Genes

GDF5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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