Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression Profiling and Functional Analysis of Candidate Col10a1 Regulators Identified by the TRAP Program

2 Jul 2021

Abstract excerpt

Hypertrophic chondrocytes and their specific marker, the type X collagen gene (Col10a1), are critical components of endochondral bone formation during skeletal development. We previously found that Runx2 is an indispensable mouse Col10a1 gene regulator and identified many other transcription factors (TFs) that potentially interact with the 150-bp Col10a1 cis-enhancer. However, the roles of these candidate TFs in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Metabolism and Diseases
Share to Osteoarthritis Treatment and Mechanisms
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34276786
DOI: 10.3389/fgene.2021.683939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression Profiling and Functional Analysis of Candidate Col10a1 Regulators Identified by the TRAP ProgramPMID 34276786Read ↗

Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiationSemantic proximity Read ↗

Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte–specific expression in vivoSemantic proximity Read ↗

Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal developmentSemantic proximity Read ↗

Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer.Semantic proximity Read ↗

Chondrocyte-specific Enhancer Elements in the Col11a2 Gene Resemble the Col2a1 Tissue-specific EnhancerSemantic proximity Read ↗

A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc developmentSemantic proximity Read ↗

HOXA10 promotes Gdf5 expression in articular chondrocytesSemantic proximity Read ↗

Identification of the core element responsive to runt‐related transcription factor 2 in the promoter of human type x collagen geneSemantic proximity Read ↗

Skeletal cell YAP and TAZ redundantly promote bone development by regulation of collagen I expression and organizationSemantic proximity Read ↗

Potential interactions between the TBX4-FGF10 and SHH-FOXF1 signaling during human lung development revealed using ChIP-seqSemantic proximity Read ↗

Lineage-specific differences and regulatory networks governing human chondrocyte developmentSemantic proximity Read ↗

Lineage-Specific Differences and Regulatory Networks Governing Human Chondrocyte DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.