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Article

Complex Regulatory Interactions at GDF5 Shape Joint Morphology and Osteoarthritis Disease Risk

13 May 2025

Abstract excerpt

OBJECTIVE: The objective of this study was to reveal causal-level osteoarthritis (OA) disease biology by targeting regulatory interactions at GDF5. METHODS: By investigating different GDF5 regulatory regions (R2, R3-R5, R7-R9, R18-R20, GROW1), we explored their functional impacts on gene expression and joint morphology in vivo and in vitro. We additionally modeled OA variants in said enhancers in in vitro and in...

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Connective Tissue Growth Factor Research
Osteoarthritis Treatment and Mechanisms
Rheumatoid Arthritis Research and Therapies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40356240
DOI: 10.1002/art.43231

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