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Article

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis.

Scientific reports - 13 Jan 2020

Kania Karolina, Colella Fabio, Riemen Anna H K, Wang Hui, Howard Kenneth A, Aigner Thomas, Dell'Accio Francesco, Capellini Terence D, Roelofs Anke J, De Bari Cosimo

Abstract excerpt

Growth and Differentiation Factor 5 (GDF5) is a key risk locus for osteoarthritis (OA). However, little is known regarding regulation of Gdf5 expression following joint tissue damage. Here, we employed Gdf5-LacZ reporter mouse lines to assess the spatiotemporal activity of Gdf5 regulatory sequences in experimental OA following destabilisation of the medial meniscus (DMM) and after acute cartilage injury and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31932746
DOI: 10.1038/s41598-019-57011-8
PMCID: PMC6957535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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