Article

Complex regulatory interactions at <i>GDF5</i> shape joint morphology and osteoarthritis disease risk

2024-11-02

Abstract excerpt

Our ability to pinpoint causal variants using GWAS is dependent on understanding the dynamic epigenomic and epistatic context of each associated locus. Being the best studied skeletal locus, GDF5 associates with many diseases and has a complex cis-regulatory architecture. We interrogate GDF5 regulatory interactions and model disease variants in vitro and in vivo . For all regulatory regions we see that local e...

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Literature Corpus work: b800826a-3feb-5f06-b794-5e1abeacba5d
DOI: 10.1101/2024.11.01.621374

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