Article
Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index.
International journal of epidemiology - 10 Aug 2022
Hartley April, Sanderson Eleanor, Granell Raquel, Paternoster Lavinia, Zheng Jie, Smith George Davey, Southam Lorraine, Hatzikotoulas Konstantinos, Boer Cindy G, van Meurs Joyce, Zeggini Eleftheria, Gregson Celia L, Tobias Jon H
Abstract excerpt
OBJECTIVES: Observational analyses suggest that high bone mineral density (BMD) is a risk factor for osteoarthritis (OA); it is unclear whether this represents a causal effect or shared aetiology and whether these relationships are body mass index (BMI)-independent. We performed bidirectional Mendelian randomization (MR) to uncover the causal pathways between BMD, BMI and OA. METHODS: One-sample (1S)MR estimates...
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