Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.

Alzheimer's research & therapy - 12 Dec 2023

Lancaster Thomas, Creese Byron, Escott-Price Valentina, Driver Ian, Menzies Georgina, Khan Zunera, Corbett Anne, Ballard Clive, Williams Julie, Murphy Kevin, Chandler Hannah

Abstract excerpt

BACKGROUND: Genome-wide association studies demonstrate that Alzheimer's disease (AD) has a highly polygenic architecture, where thousands of independent genetic variants explain risk with high classification accuracy. This AD polygenic risk score (AD-PRS) has been previously linked to preclinical cognitive and neuroimaging features observed in asymptomatic individuals. However, shared variance between AD-PRS and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Genotype

Share to Gyrus Cinguli

Share to Neuroimaging

Source

Open in PubMed Open full text

Identifiers

PMID: 38087383
DOI: 10.1186/s13195-023-01362-y
PMCID: PMC10714651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.PMID 38087383Read ↗

Polygenic risk of Alzheimer disease is associated with early- and late-life processes.Semantic proximity Read ↗

Polygenic risk for Alzheimer's disease in healthy aging: age-related and APOE-driven effects on brain structures and cognition.Semantic proximity Read ↗

Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank.Semantic proximity Read ↗

Multimodal Brain Imaging Reveals Structural Differences in Alzheimer's Disease Polygenic Risk Carriers: A Study in Healthy Young Adults.Semantic proximity Read ↗

Age-related polygenic effects of Alzheimer's disease on brain structures and cognition in middle aged and elderly adults from UK BiobankSemantic proximity Read ↗

Genetic risk for Alzheimer’s disease predicts hippocampal volume through the lifespanSemantic proximity Read ↗

Testing a polygenic risk score for morphological microglial activation in Alzheimer’s disease and agingSemantic proximity Read ↗

Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.Semantic proximity Read ↗

White Matter Microstructural Alterations Mediate the Association between Polygenic Risk for Alzheimer's Disease and Cognitive Performance in Clinically Asymptomatic Adults.Semantic proximity Read ↗

Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participantsSemantic proximity Read ↗

Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participantsSemantic proximity Read ↗

An Alzheimer's Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.