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Article

DNA methylation modulated genetic variant effect on gene transcriptional regulation.

Genome biology - 8 Dec 2023

Zeng Yong, Jain Rahi, Lam Magnus, Ahmed Musaddeque, Guo Haiyang, Xu Wenjie, Zhong Yuan, Wei Gong-Hong, Xu Wei, He Housheng Hansen

Abstract excerpt

BACKGROUND: Expression quantitative trait locus (eQTL) analysis has emerged as an important tool in elucidating the link between genetic variants and gene expression, thereby bridging the gap between risk SNPs and associated diseases. We recently identified and validated a specific case where the methylation of a CpG site influences the relationship between the genetic variant and gene expression. RESULTS: Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38066556
DOI: 10.1186/s13059-023-03130-5
PMCID: PMC10709945

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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