Article

Disease variants alter transcription factor levels and methylation of their binding sites

2015-11-30

Abstract excerpt

Most disease associated genetic risk factors are non-coding, making it challenging to design experiments to understand their functional consequences. Identification of expression quantitative trait loci (eQTLs) has been a powerful approach to infer downstream effects of disease variants but the large majority remains unexplained.. The analysis of DNA methylation, a key component of the epigenome, offers highly com...

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Literature Corpus work: f6f22b8d-6fcf-5944-aa9e-90e9b1fd9ad9
DOI: 10.1101/033084

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