Article

Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal Cancer

2026-06-23

Abstract excerpt

<title>Abstract</title> <p> Colorectal cancer (CRC) tumours with high stromal content have a worse outcome, but the mechanisms governing this are unclear. Using high-throughput single-cell perturbation analysis of CRC patient-derived organoids (PDOs) and cancer-associated fibroblasts (CAFs) we find that epithelial cells with high stromal-communication potential are marked by the transcriptional co-repressor <it...

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Literature Corpus work: 4617f21b-88ed-5e39-b93e-7c52b89521c1
DOI: 10.21203/rs.3.rs-10019683/v1

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