Article

Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal Cancer

2026-06-18

Abstract excerpt

Colorectal cancer (CRC) tumours with high stromal content have a worse outcome, but the mechanisms governing this are unclear. Using high-throughput single-cell perturbation analysis of CRC patient-derived organoids (PDOs) and cancer-associated fibroblasts (CAFs) we find that epithelial cells with high stromal-communication potential are marked by the transcriptional co-repressor DACH1 . To define the causal regu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97649da1-965d-5530-aa5e-772081559dac
DOI: 10.64898/2026.06.14.732116

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal CancerDOI 10.64898/2026.06.14.732116Read

Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal CancerSemantic proximity Read

An oncogenic phenoscape of colonic stem cell polarizationSemantic proximity Read

Perturbation-guided mapping of colorectal cancer cell states to causal mechanismsSemantic proximity Read

Epigenetic evolution of colorectal cancer and its microenvironment reveals new vulnerabilitiesSemantic proximity Read

CD44+ cells enhance pro-tumor stroma in the spatial landscape of colorectal cancer leading edgeSemantic proximity Read

Oncogenic signalling is coupled to colorectal cancer cell differentiation stateSemantic proximity Read

Revisiting colorectal cancer tumorigenesis with spatially-resolved gene expression profilingSemantic proximity Read

CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancerSemantic proximity Read

Enhancer-gene regulatory interactions in colorectal cancer revealed through genome-wide CRISPRi perturbationsSemantic proximity Read

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancerSemantic proximity Read

Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signallingSemantic proximity Read

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiationSemantic proximity Read