Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers.

doi:10.1164/rccm.202106-1458OC

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Article

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers.

American journal of respiratory and critical care medicine - 15 Mar 2022

Illi Sabina, Depner Martin, Pfefferle Petra Ina, Renz Harald, Roduit Caroline, Taft Diana Hazard, Kalanetra Karen M, Mills David A, Farquharson Freda M, Louis Petra, Schmausser-Hechfellner Elisabeth, Divaret-Chauveau Amandine, Lauener Roger, Karvonen Anne M, Pekkanen Juha, Kirjavainen Pirkka V, Roponen Marjut, Riedler Josef, Kabesch Michael, Schaub Bianca, von Mutius Erika

Abstract excerpt

Rationale: In murine models, microbial exposures induce protection from experimental allergic asthma through innate immunity. Objectives: Our aim was to assess the association of early life innate immunity with the development of asthma in children at risk. Methods: In the PASTURE farm birth cohort, innate T-helper cell type 2 (Th2), Th1, and Th17 cytokine expression at age 1 year was measured after stimulation...

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Identifiers

PMID: 34919021
DOI: 10.1164/rccm.202106-1458OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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