Upper airway microbiome interacts with GSDMB and ORMDL3 asthma risk SNPs to influence early-life wheeze risk.

doi:10.1016/j.jaci.2026.05.021

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Article

Upper airway microbiome interacts with GSDMB and ORMDL3 asthma risk SNPs to influence early-life wheeze risk.

The Journal of allergy and clinical immunology - 1 Sept 2026

Steininger Holly M, McCauley Kathryn E, Braga Gabe E, Morin Andréanne, Lee Kristine E, Visness Cynthia M, Fadrosh Douglas W, Dapas Matthew, O'Connor George T, Bacharier Leonard B, Rivera-Spoljaric Katherine, Kattan Meyer, Lemanske Robert F, Zoratti Edward M, Martinez Fernando D, Gold Diane R, Hartert Tina V, Johnson Christine C, Miller Rachel L, Seroogy Christine M, Wood Robert A, Togias Alkis, Jackson Daniel J, Gern James E, Ober Carole, Lynch Susan V

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms (SNPs) in the chromosome 17q12-q21 region and, independently, early-life nasal microbiota dominated by Moraxella, Streptococcus, or Haemophilus (MSH) increase risk of chronic wheeze and asthma development. OBJECTIVE: We sought to determine whether 17q12-q21 risk SNPs and nasal microbiota interact to modulate childhood wheeze risk. METHODS: Nasal wash samples from...

Read the complete abstract on PubMed

Topics

Humans
Polymorphism, Single Nucleotide
Microbiota

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Asthma

Respiratory Sounds

Female

Infant

Male

Membrane Proteins

Gasdermins

Genetic Predisposition to Disease

Chromosomes, Human, Pair 17

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 42248217
DOI: 10.1016/j.jaci.2026.05.021

Genes

GSDMB
ORMDL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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