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Article

Small synthetic molecule-stabilized RNA pseudoknot as an activator for –1 ribosomal frameshifting

31 Jul 2018

Abstract excerpt

Programmed -1 ribosomal frameshifting (-1PRF) is a recoding mechanism to make alternative proteins from a single mRNA transcript. -1PRF is stimulated by cis-acting signals in mRNA, a seven-nucleotide slippery sequence and a downstream secondary structure element, which is often a pseudoknot. In this study we engineered the frameshifting pseudoknot from the mouse mammary tumor virus to respond to a rationally...

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PMID: 30085309
DOI: 10.1093/nar/gky689

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