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Article

Constitutional BRCA1 and MGMT Methylation Are Significant Risk Factors for Triple-Negative Breast Cancer and High-Grade Serous Ovarian Cancer in Saudi Women.

International journal of molecular sciences - 7 Mar 2024

Al-Moghrabi Nisreen, Al-Showimi Maram, Alqahtani Amal, Almalik Osama, Alhusaini Hamed, Almalki Ghdah, Saad Ajawhara, Alsunayi Elaf

Abstract excerpt

Breast cancer (BC) and ovarian cancer (OC) are rapidly increasing in Saudi Arabia. BRCA1 and MGMT epimutations have been linked to a higher risk of these malignancies. The present research investigated the impact of these epimutations on the prevalence of BC and OC among Saudi women. DNA methylation was evaluated using methylation-specific PCR, whereas mRNA expression levels were assessed using qRT-PCR. We...

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Identifiers

PMID: 38542081
DOI: 10.3390/ijms25063108
PMCID: PMC10970267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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