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Article

Naturally arising memory-phenotype CD4+ T lymphocytes contain an undifferentiated population that can generate TH1, TH17, and Treg cells.

Science advances - 6 Dec 2024

Kawajiri Akihisa, Li Jing, Koinuma Keita, Yang Ziying, Yoon Hye Jin, Yi Jaeu, Nagashima Hiroyuki, Ishii Minami, Gao Feng, Sato Kosuke, Tayama Shunichi, Harigae Hideo, Iwakura Yoichiro, Ishii Naoto, Sher Alan, Ishigaki Kazuyoshi, Zhu Jinfang, Kim Kwang Soon, Kawabe Takeshi

Abstract excerpt

Memory-phenotype (MP) CD4+ T lymphocytes develop from naïve cells via self-recognition at homeostasis. While previous studies defined MP cells as a heterogeneous population that comprises T helper 1 (TH1)/17-like subsets, functional significance of the T-bet- Rorγt- subpopulation remains unknown. Here we show that MP lymphocytes as a whole population can differentiate into TH1/17/regulatory T (Treg) cells to...

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Identifiers

PMID: 39630890
DOI: 10.1126/sciadv.adq6618
PMCID: PMC11619248

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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