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Circulating Tumor DNA Profiling Approach Based on In Silico Background Elimination Guides Chemotherapy in Nasopharyngeal Carcinoma.

Clinical pharmacology and therapeutics - 1 May 2024

Li Ming, Xie Sisi, Hou Tao, Shao Tong, Kuang Jingyu, Liu Chuanyang, Qu Ying, Lu Chenyu, Liu Jiali, Liu Xianling, Zhu Lingyun, Zhu Lvyun

Abstract excerpt

Circulating tumor DNA (ctDNA) analysis increasingly provides a promising minimally invasive alternative to tissue biopsies in precision oncology. However, there are no ctDNA analysis approaches available in nasopharyngeal carcinoma (NPC) and current methods of ctDNA mutation profiling have limited resolution because of the high background noise and false-positive rate caused by benign variants in plasma cell-free...

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PMID: 38037868
DOI: 10.1002/cpt.3125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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