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Article

Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature communications - 4 Jan 2021

Zhang Yongliang, Yao Yu, Xu Yaping, Li Lifeng, Gong Yan, Zhang Kai, Zhang Meng, Guan Yanfang, Chang Lianpeng, Xia Xuefeng, Li Lin, Jia Shuqin, Zeng Qiang

Abstract excerpt

Circulating tumor DNA (ctDNA) provides a noninvasive approach to elucidate a patient's genomic landscape and actionable information. Here, we design a ctDNA-based study of over 10,000 pan-cancer Chinese patients. Using parallel sequencing between plasma and white blood cells, 14% of plasma cell-free DNA samples contain clonal hematopoiesis (CH) variants, for which detectability increases with age. After...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33397889
DOI: 10.1038/s41467-020-20162-8
PMCID: PMC7782482

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