Clonal Hematopoiesis in Lung Cancer and Its Impact on Liquid Biopsy Based on Targeted Deep Sequencing

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Blood based liquid biopsy has proved its potential in enormous clinical applications, such as cancer screening, diagnosis, treatment guidance, disease tracking and monitoring. In certain scenario (e.g., molecular residual disease), it requires the technique to be able to detect mutation with very low frequency (0.001% ~ 1%). The major hurdle of ultra-sensitive c...

Topics

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• Cell-Free Nucleic Acids
• Clonal Hematopoiesis
• Computational Biology
• Gene Library
• Gene Ontology
• Germ-Line Mutation
• High-Throughput Nucleotide Sequencing
• Liquid Biopsy

Identifiers and source

Literature Corpus work

35f3c230-2863-5e06-a296-1295bf2284fa

DOI

10.21203/rs.3.rs-907910/v1