Article

Circulating tumor DNA profiling approach based on in silico background elimination guides patient classification of multiple cancers

2022-08-05

Abstract excerpt

Circulating tumor DNA (ctDNA) analysis is increasingly providing a promising minimally invasive alternative to tissue biopsies in precision oncology. However, current methods of ctDNA mutation profiling have limited resolution because of the high background noise and false-positive rate caused by benign variants in plasma cell-free DNA (cfDNA), majorly generated during clonal hematopoiesis. Although personalized p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c652aecb-2dd9-59c2-bc92-b6d78b1fb435
DOI: 10.1101/2022.08.04.502459

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Circulating tumor DNA profiling approach based on in silico background elimination guides patient classification of multiple cancersDOI 10.1101/2022.08.04.502459Read

Circulating Tumor DNA Profiling Approach Based on In Silico Background Elimination Guides Chemotherapy in Nasopharyngeal Carcinoma.Semantic proximity Read

Noninvasive MRD monitoring and profiling of clonal evolution by ctDNA in patients with advanced cancers treated within molecular tumor boardsSemantic proximity Read

Integrative modeling of tumor genomes and epigenomes for enhanced cancer diagnosis by cell-free DNA.Semantic proximity Read

Detection of Circulating Tumor DNA in Plasma Using Targeted Sequencing.Semantic proximity Read

Analytical and Clinical Validation of Cell-Free Circulating Tumor DNA Assay for the Estimation of Tumor Mutational Burden.Semantic proximity Read

A novel virtual barcode strategy for accurate panel-wide variant calling in circulating tumor DNASemantic proximity Read

Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoringSemantic proximity Read

Beyond basics: Key mutation selection features for successful tumor-informed ctDNA detection.Semantic proximity Read

The potential of combined mutation sequencing of plasma circulating cell-free DNA and matched white blood cells for treatment response prediction.Semantic proximity Read

A novel virtual barcode strategy for accurate panel-wide variant calling in circulating tumor DNA.Semantic proximity Read

Evaluation of cell-free DNA approaches for multi-cancer early detectionSemantic proximity Read

Baseline mutation profiling of 1134 samples of circulating cell-free DNA and blood cells from healthy individualsSemantic proximity Read