Article

Overlooked roles of DNA damage and maternal age in generating human germline mutations

2018-05-21

Abstract excerpt

Although the textbook view is that most germline mutations arise from replication errors, when analyzing large de novo mutation datasets in humans, we find multiple lines of evidence that call that understanding into question. Notably, despite the drastic increase in the ratio of male to female germ cell divisions after the onset of spermatogenesis, even young fathers contribute three times more mutations than yo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2aba033d-054b-5538-be15-8ff5b236c9b5
DOI: 10.1101/327098

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overlooked roles of DNA damage and maternal age in generating human germline mutationsDOI 10.1101/327098Read

The 'faulty male' hypothesis for sex-biased mutation and disease.Semantic proximity Read

Paternal age, de novo mutations, and offspring health? New directions for an ageing problem.Semantic proximity Read

Signatures of replication timing, recombination and sex in the spectrum of rare variants on the human X chromosome and autosomesSemantic proximity Read

The Sins of Our Forefathers: Paternal Impacts on De Novo Mutation Rate and Development.Semantic proximity Read

The “faulty male” hypothesis: implications for evolution and diseaseSemantic proximity Read

Male-driven de novo mutations in haploid germ cells.Semantic proximity Read

Transgenerational effects of paternal exposures: the role of germline de novo mutationsSemantic proximity Read

The impact of paternal age on new mutations and disease in the next generation.Semantic proximity Read

Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line.Semantic proximity Read

Sex differences in transcription-associated mutagenesis in the human germlineSemantic proximity Read

A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell division numbers.Semantic proximity Read

A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell divisionsSemantic proximity Read