Article
Break-induced replication forms long mutable single-strand DNA during meiosis.
Nature communications - 20 Jun 2026
Twarowski Jerzy M, Kramara Juraj, Seuferer Gabriel J, Renninger Kelley A, Comeron Josep M, Malkova Anna
Abstract excerpt
In meiosis, homologous recombination (HR) facilitates the halving of genomic content in diploid parents to produce haploid gametes, while also reshuffling genetic material. However, studies in yeast and mammals have suggested that HR during meiosis also makes the process mutagenic, and it has been proposed that the single-strand (ss) DNA formed by HR of programmed double-strand breaks (DSBs) contributes to the...
Topics
- Meiosis
- DNA, Single-Stranded
- DNA Replication
- Saccharomyces cerevisiae
- DNA Breaks, Double-Stranded
- Mutagenesis
- Humans
- Mutation
- Cytidine Deaminase
- Endodeoxyribonucleases
- Saccharomyces cerevisiae Proteins
- Meiotic Recombination Protein SPO11
- Homologous Recombination