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Article

FOXP3 recognizes microsatellites and bridges DNA through multimerization.

Nature - 1 Dec 2023

Zhang Wenxiang, Leng Fangwei, Wang Xi, Ramirez Ricardo N, Park Jinseok, Benoist Christophe, Hur Sun

Abstract excerpt

FOXP3 is a transcription factor that is essential for the development of regulatory T cells, a branch of T cells that suppress excessive inflammation and autoimmunity1-5. However, the molecular mechanisms of FOXP3 remain unclear. Here we here show that FOXP3 uses the forkhead domain-a DNA-binding domain that is commonly thought to function as a monomer or dimer-to form a higher-order multimer after binding to TnG...

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Share to Consensus Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38030726
DOI: 10.1038/s41586-023-06793-z
PMCID: PMC10719092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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