Article

FoxP3 recognizes microsatellites and bridges DNA through multimerization

2023-07-12

Abstract excerpt

FoxP3 is a transcription factor (TF) essential for development of regulatory T cells (Tregs), a branch of T cells that suppress excessive inflammation and autoimmunity 1-5 . Molecular mechanisms of FoxP3, however, remain elusive. We here show that FoxP3 utilizes the Forkhead domain––a DNA binding domain (DBD) that is commonly thought to function as a monomer or dimer––to form a higher-order multimer upon binding...

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Literature Corpus work: 576ee4f5-4aea-5973-880b-c58667df9746
DOI: 10.1101/2023.07.12.548762

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