Article
Structure of the forkhead domain of FOXP2 bound to DNA.
Structure (London, England : 1993) - 1 Jan 2006
Stroud James C, Wu Yongqing, Bates Darren L, Han Aidong, Nowick Katja, Paabo Svante, Tong Harry, Chen Lin
Abstract excerpt
FOXP (FOXP1-4) is a newly defined subfamily of the forkhead box (FOX) transcription factors. A mutation in the FOXP2 forkhead domain cosegregates with a severe speech disorder, whereas several mutations in the FOXP3 forkhead domain are linked to the IPEX syndrome in human and a similar autoimmune phenotype in mice. Here we report a 1.9 A crystal structure of the forkhead domain of human FOXP2 bound to DNA. This...
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