The transcription factor Rpn4 activates its own transcription and induces efflux pump expression to confer fluconazole resistance in Candida auris

Abstract excerpt

ABSTRACT The emergence and nosocomial spread of the multidrug-resistant Candida auris pose a severe public health threat. Most C. auris clinical isolates are fluconazole resistant. In this study, we conduct transposon-mediated screens to profile genes whose inactivation causes fluconazole resistance in C. auris . We discover that mutation of genes encoding the Ubr2/Mub1 ubiquitin-ligase complex results in high...

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