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A simeprevir-inducible molecular switch for the control of cell and gene therapies

27 Nov 2023

Abstract excerpt

Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant interest within the synthetic biology community in identifying novel CID systems. To date, CID modules have been used primarily in engineering cells for in vitro applications. To broaden their utility to the clinical setting, including the potential to control...

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PMID: 38012128
DOI: 10.1038/s41467-023-43484-9

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