Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo

Abstract excerpt

Here, we report the development of target-specific binding proteins based on the kringle domain (KD) ( approximately 80 residues), a ubiquitous modular structural unit occurring across eukaryotic species. By exploiting the highly conserved backbone folding by core residues, but using extensive sequence variations in the seven loop regions of naturally occurring human KDs, we generated a synthetic KD library on...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Monoclonal and Polyclonal Antibodies Research
• Share to Peptidase Inhibition and Analysis
• Share to Toxin Mechanisms and Immunotoxins