Article

<i>In vitro</i> assessment of an engineered tBID-based safety switch system in human T lymphocytes

2021-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Cell therapy as a promising therapeutic modality to treat cancer has been intensively studied for decades. However, the clinical trials have indicated that patients under T cell therapy may develop severe cytokine release syndrome resulting in hospitalization or even death. Furthermore, genetic modifications to promote proliferation and persistence of T cells could result in high numbers of long...

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Literature Corpus work: cdb01c63-4f42-5fe3-8dd9-dae89c9054de
DOI: 10.1101/2021.01.27.428458

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