Article

Phenotypic Screening Identifies Small-Molecule Inhibitors with Distinct Activities across the BK Polyomavirus Life Cycle

2026-08-20

Abstract excerpt

<h4>BACKGROUND</h4> BK polyomavirus (BKPyV) reactivation is a major complication in kidney and hematopoietic stem cell transplant recipients, yet no specific antiviral therapy is currently available. Antiviral discovery is complicated by the restricted tropism and slow replication kinetics of BKPyV and its extensive dependence on cellular processes. <h4>RESULTS</h4> We established a phenotypic high-throughput sc...

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Literature Corpus work: 932b4706-cec0-59ef-a456-eee20cf6dcc2
DOI: 10.64898/2026.08.20.745923

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