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Regulation of T cell proliferation with drug-responsive microRNA switches

1 Dec 2017

Abstract excerpt

As molecular and cellular therapies advance in the clinic, the role of genetic regulation is becoming increasingly important for controlling therapeutic potency and safety. The emerging field of mammalian synthetic biology provides promising tools for the construction of regulatory platforms that can intervene with endogenous pathways and control cell behavior. Recent work has highlighted the development of...

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PMID: 29244152
DOI: 10.1093/nar/gkx1228

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