Article

A selective and rapid cell-permeable inhibitor of human caspase-3

2019-07-18

Abstract excerpt

<h4>ABSTRACT</h4> The individual roles and overlapping functionalities the twelve human caspases have during apoptosis and other cellular processes remain poorly resolved primarily due to a lack of chemical tools. Here we present a new selective caspase-3 inhibitor, termed Ac-ATS010-KE, with rapid and irreversible binding kinetics. Relative to previously designed caspase-3-selective molecules that have tremendous...

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Literature Corpus work: 2956bab0-18b4-5fac-951c-8358f68b12a4
DOI: 10.1101/706614

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