Article
Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.
Journal of clinical hypertension (Greenwich, Conn.) - 1 Jan 2024
Zhang Xi, Yao Shi, Bao Peng, Du Mingfei, Hu Guilin, Chu Chao, Wang Dan, Chen Chen, Ma Qiong, Jia Hao, Sun Yue, Yan Yu, Liao Yueyuan, Niu Zejiaxin, Man Ziyue, Wang Lan, Gao Weihua, Li Hao, Zhang Jie, Luo Wenjing, Wang Xin, Wang Yang, Mu Jianjun
Abstract excerpt
Recent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a member of the G-protein coupled receptor superfamily, encoded by the CHRM3 gene, in cardiac function and the regulation of blood pressure (BP). The aim of this study was to investigate the associations of CHRM3 genetic variants with salt sensitivity, longitudinal BP changes, and the development of hypertension in a Chinese...
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