Article
Novel genetic variants in the alpha-adducin and guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood pressure.
American journal of hypertension - 1 Sept 2009
Kelly Tanika N, Rice Treva K, Gu Dongfeng, Hixson James E, Chen Jing, Liu Depei, Jaquish Cashell E, Bazzano Lydia A, Hu Dongsheng, Ma Jixiang, Gu C Charles, Huang Jianfeng, Hamm L Lee, He Jiang
Abstract excerpt
BACKGROUND: We examined the association between 12 single-nucleotide polymorphisms (SNPs) in the alpha-adducin (ADD1) and guanine nucleotide binding protein (G protein) beta-polypeptide 3 (GNB3) genes and systolic (SBP), diastolic (DBP), and mean arterial (MAP) pressure responses to salt intake. METHODS: A 7-day low-sodium (51.3 mmol sodium/day) followed by a 7-day high-sodium intervention (307.8 mmol sodium/day)...
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